Polymeric micelles work by encapsulating anticancer drugs in their hydrophobic core, thereby improving the solubility and stability of the drugs. The hydrophilic shell of the micelle helps in prolonging the circulation time of the drug in the bloodstream, thereby increasing its accumulation in tumor tissues via the Enhanced Permeability and Retention (EPR) effect. This targeted delivery minimizes the adverse effects on healthy tissues and enhances the therapeutic efficacy of the drug.
