How Do Proton Pumps Influence Tumor Microenvironment?
Proton pumps, particularly the V-ATPase, are involved in regulating the pH of intracellular compartments and the extracellular environment. In cancer, increased activity of proton pumps can lead to an acidic tumor microenvironment, which promotes tumor invasion and metastasis. Inhibiting these pumps could potentially disrupt the tumor microenvironment and inhibit cancer progression.
