The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and it is crucial for transmitting information from extracellular chemical signals to the cell nucleus, resulting in DNA transcription and cellular events such as proliferation, differentiation, and apoptosis. This pathway involves cytokine receptors, Janus kinases (JAKs), and Signal Transducers and Activators of Transcription (STATs).