What is the Role of Biomarkers in T Cell Exhaustion?
Biomarkers are crucial for identifying and targeting exhausted T cells. The expression of inhibitory receptors such as PD-1, CTLA-4, TIM-3, and LAG-3 can serve as markers of exhaustion. Additionally, transcription factors like TOX have been linked to the exhausted phenotype. Biomarker studies can help in patient selection and monitoring the efficacy of immunotherapies.
