How do Pro Inflammatory Cytokines Contribute to Cancer?
Pro inflammatory cytokines contribute to cancer through several mechanisms. Chronic inflammation initiated by these cytokines can lead to DNA damage, promoting mutations and genomic instability. Additionally, cytokines can create a microenvironment that supports tumor growth, angiogenesis, and metastasis. For instance, IL-6 is known to enhance the survival of malignant cells and promote angiogenesis, which is the formation of new blood vessels that supply the tumor with nutrients and oxygen.
