How Do Prophase-Targeting Drugs Lead to Cell Death?
Prophase-targeting drugs interfere with the assembly or stability of the [mitotic spindle](), preventing the accurate segregation of chromosomes. This mitotic arrest activates the [spindle assembly checkpoint](), leading to prolonged arrest or mitotic catastrophe. If the damage is irreparable, cells may undergo [apoptosis](), a programmed cell death pathway, or [necrosis](), an uncontrolled form of cell death, thereby reducing tumor growth.
