Can Prophase Serve as a Target for Cancer Treatment?
Yes, targeting the molecular events during prophase can be an effective strategy for cancer treatment. Drugs like [taxanes]() and [vinca alkaloids]() disrupt microtubule dynamics, impairing spindle formation and arresting cells in prophase or metaphase. These treatments exploit the reliance of rapidly dividing cancer cells on proper mitotic progression, leading to cell death. However, resistance mechanisms can develop, necessitating combination therapies or novel agents.
