How do TCRs compare to CAR T cells in cancer therapy?
Both TCRs and CAR T cells are forms of adoptive cell therapy, but they differ in their mechanisms for recognizing antigens. TCRs recognize antigens presented by MHC molecules, which limits their use to specific HLA types. CAR T cells, however, are engineered to recognize antigens independent of MHC, allowing for broader applicability. CAR T cell therapy has shown success in certain blood cancers, while TCR therapy holds promise for targeting intracellular tumor antigens.
