These advanced techniques improve outcomes by providing a more accurate representation of how drugs will behave in the human body. For instance, 3D cell cultures and organoids can better mimic the tumor microenvironment, leading to more reliable predictions of drug efficacy and toxicity. CRISPR-Cas9 screening allows for targeted investigations into specific genes and pathways, helping researchers understand the underlying mechanisms of drug resistance and sensitivity. AI and machine learning can process large volumes of data to identify patterns and potential drug candidates that might be missed by human analysis.