Tumor cells navigate through tissues using a process known as the epithelial-to-mesenchymal transition (EMT), which involves the loss of epithelial characteristics and the gain of mesenchymal traits, providing cells with increased mobility. During EMT, cells undergo cytoskeletal reorganization, which is essential for movement. Tumor cells also secrete enzymes like matrix metalloproteinases (MMPs) that degrade ECM components, creating pathways for invasion.
