How Do Tumor Suppressors and Oncogenes Affect the Cell Cycle?
Tumor suppressor genes and oncogenes play opposing roles in cell cycle regulation. Tumor suppressors, such as RB1 and TP53, act as brakes on the cell cycle, preventing uncontrolled division. In contrast, oncogenes like MYC and RAS act as accelerators, promoting cell proliferation. Mutations in these genes can disrupt the balance between cell growth and inhibition, leading to cancer.
