What Therapeutic Strategies Target Cell Cycle Regulation in Cancer?
Targeting cell cycle regulation is a promising strategy for cancer therapy. CDK inhibitors (e.g., palbociclib) have been developed to block the activity of specific CDKs, thereby halting cancer cell proliferation. Another approach involves targeting the proteins involved in cell cycle checkpoints. For example, CHK1/CHK2 inhibitors can enhance the effectiveness of DNA-damaging agents by preventing cancer cells from repairing DNA damage.
