The UCSF Criteria are often compared to the Milan Criteria, which are more stringent. While the Milan Criteria stipulate a single tumor no larger than 5 cm or up to three tumors each no larger than 3 cm, the UCSF Criteria provide a more lenient framework. This flexibility allows for the inclusion of patients who would otherwise be excluded, potentially improving access to life-saving treatments. However, the UCSF Criteria still maintain a focus on minimizing recurrence risk, aligning with the overarching goal of optimizing patient outcomes.