How Does BrdU Compare to Other Proliferation Markers?
Several other markers, such as Ki-67 and PCNA, are also used to study cell proliferation. Compared to these markers: - BrdU specifically labels cells that are in the S-phase, providing a more direct measure of DNA synthesis. - Ki-67 is present during all active phases of the cell cycle but not during the resting phase, making it less specific than BrdU for DNA synthesis. - PCNA is involved in DNA repair as well as replication, which can complicate its interpretation.
