In normal cells, β Catenin is regulated tightly by a destruction complex that includes Axin, APC (adenomatous polyposis coli), CK1 (casein kinase 1), and GSK-3β (glycogen synthase kinase 3 beta). When the Wnt ligand binds to its receptor, this destruction complex is inhibited, allowing β Catenin to accumulate in the cytoplasm and eventually translocate to the nucleus where it activates transcription factors such as TCF/LEF.
