Which cancers are most commonly associated with β Catenin dysregulation?
β Catenin dysregulation is most commonly associated with colorectal cancer, where mutations in the APC gene lead to the stabilization and accumulation of β Catenin. Other cancers with frequent β Catenin dysregulation include hepatocellular carcinoma, melanoma, and ovarian cancer. In these cancers, the abnormal activation of β Catenin-driven transcriptional programs promotes cellular proliferation, survival, and metastasis.
