How Does Clonal Evolution Contribute to Tumor Heterogeneity?
Clonal evolution leads to intratumor heterogeneity, which is the presence of genetically diverse subpopulations within a single tumor. This heterogeneity complicates treatment, as different clones may respond differently to therapies. It also poses a challenge for diagnostic procedures, as sampling from one region of the tumor may not represent the genetic landscape of the entire tumor.
