How Does Dysregulated Transcription Contribute to Cancer?
In cancer, the regulation of transcription is often disrupted. This can be due to mutations in oncogenes or tumor suppressor genes, which can lead to the overexpression or underexpression of genes that control cell growth and division. For example, mutations in the TP53 gene, a well-known tumor suppressor, can result in the loss of its ability to regulate the cell cycle and induce apoptosis, thereby promoting cancer development.
