Mutations or overexpression of EGFR can lead to uncontrolled cell proliferation, a hallmark of cancer. When EGFR is mutated, it can be constantly active without the need for binding to its ligand, leading to continuous signals for cell division. This uncontrolled growth can result in the formation of tumors. EGFR mutations are particularly common in non-small cell lung cancer (NSCLC) and are a target for several cancer therapies.
