HTS involves the use of robotics, data processing, and control software, liquid handling devices, and sensitive detectors to identify active compounds, antibodies, or genes. The process typically includes the following steps: 1. Compound Library Preparation: A large collection of potential therapeutic agents are prepared. 2. Assay Development: A reliable and reproducible bioassay is developed to test the compounds. 3. Screening: Compounds are tested against a biological target. 4. Data Analysis: Results are analyzed to identify "hits" - compounds that show desired activity.