How Does Interstitial Fluid Affect Tumor Metastasis?
Interstitial fluid, a component of ECF, fills the spaces between cells and tissues. In tumors, increased interstitial fluid pressure is a common feature. This pressure can promote cancer cell detachment from the primary tumor and facilitate entry into the lymphatic and vascular systems, aiding in metastasis. Moreover, the composition of interstitial fluid, including its cytokines and growth factors, can create a permissive environment for tumor spread.
