PERK contributes to tumor progression through several mechanisms:
Cell Survival: By reducing protein synthesis, PERK helps cancer cells survive under adverse conditions. Angiogenesis: PERK activation can promote the expression of pro-angiogenic factors, facilitating blood vessel formation to supply the growing tumor. Metastasis: PERK signaling has been implicated in enhancing the invasive and metastatic capabilities of cancer cells. Chemoresistance: PERK-mediated stress responses can make cancer cells more resistant to chemotherapy and other treatments.
