PKR-like ER kinase (PERK) is an important enzyme involved in the unfolded protein response (UPR) within the endoplasmic reticulum (ER). PERK is a type-I transmembrane protein that senses stress in the ER and initiates protective signaling pathways to restore normal function. When misfolded proteins accumulate in the ER, PERK is activated and helps to alleviate stress by reducing overall protein synthesis and activating specific stress-response genes.
