The technique involves using external devices to apply heat to the targeted area, usually achieving temperatures between 104°F and 113°F (40°C to 45°C). The heat can be delivered using various methods, including microwave, radiofrequency, and ultrasound. By increasing the temperature of the tumor, the treatment can cause protein denaturation and disrupt the cell membrane, leading to cell death or making the cancer cells more susceptible to other treatments.