How Can HLA Class II Influence Cancer Immunotherapy?
HLA Class II molecules are critical in the success of many cancer immunotherapies, including cancer vaccines and adoptive T cell therapies. They help present tumor antigens to immune cells, facilitating a targeted immune response. Therapies that enhance the expression of HLA Class II on tumor cells or improve antigen presentation can boost the efficacy of immunotherapies. Additionally, identifying specific HLA alleles that predict better responses to treatment can personalize and optimize cancer therapies.
