What is the Role of HLA Class II Polymorphism in Cancer?
HLA Class II molecules are highly polymorphic, meaning there is a vast diversity in the HLA gene variants, which influences an individual's immune response capability. This polymorphism can affect cancer susceptibility and therapeutic outcomes. Certain HLA Class II alleles have been linked to a higher or lower risk of developing specific types of cancer. Moreover, the diversity in HLA types can impact the effectiveness of immunotherapies, such as checkpoint inhibitors, as these treatments often rely on the body's immune system to recognize and destroy cancer cells.
