How Does Silencing Contribute to Cancer Development?
The silencing of tumor suppressor genes removes critical checks and balances in cell proliferation, enabling uncontrolled cell growth and division, which are hallmarks of cancer. For example, the loss of function of the TP53 gene, commonly referred to as the "guardian of the genome," leads to the accumulation of genetic mutations, increased cell survival, and resistance to apoptosis. Similarly, the inactivation of the RB1 gene disrupts the regulation of the cell cycle, facilitating the transition from the G1 to the S phase and promoting tumor progression.
