How Does STING Interact with Other Immune Pathways?
The STING pathway interacts with several other immune pathways, including the NF-κB and IRF3 pathways. Upon activation, STING triggers the phosphorylation and activation of TBK1 and IRF3, leading to the production of type I interferons. It also activates the NF-κB pathway, contributing to the production of pro-inflammatory cytokines. These interactions amplify the immune response against cancer cells, making the STING pathway a central hub in the anti-tumor immune response.
