TBP can contribute to tumorigenesis through several mechanisms:
Altered Expression: Changes in the levels of TBP can disrupt the balance of gene expression, leading to either the overexpression of oncogenes or the underexpression of tumor suppressor genes. Mutations: Mutations within the TBP gene can result in a non-functional protein that cannot accurately initiate transcription, causing widespread transcriptional errors. Interaction with Other Proteins: TBP interacts with various co-activators and co-repressors. Alterations in these interactions can modify the transcriptional landscape, potentially leading to cancer.
