The Bliss Independence Model operates on the principle of independent action. If Drug A kills a certain percentage of cancer cells and Drug B kills another percentage, the combined effect can be predicted by multiplying the probabilities of their individual actions. Mathematically, if P(A) is the probability of response to Drug A and P(B) is the probability of response to Drug B, the combined effect P(AB) is given by: P(AB) = P(A) + P(B) - P(A) * P(B)
