How Does the Loss of E-Cadherin Affect Cancer Cells?
E-cadherin is a key molecule in maintaining cell-cell adhesion in epithelial tissues. The loss or dysfunction of E-cadherin disrupts cell-cell adhesion, leading to increased cellular motility and invasiveness. This process is a hallmark of the epithelial-mesenchymal transition (EMT), a critical step in cancer metastasis.
