The SCN influences various biological processes, including cell cycle regulation, DNA repair, and apoptosis, which are critical in preventing cancer. Disruption of the SCN, often through lifestyle factors such as shift work or jet lag, can lead to desynchronized peripheral clocks. This desynchronization may cause genomic instability, impaired immune function, and increased inflammation, all of which can elevate cancer risk. Studies have shown that individuals with chronic circadian disruption have a higher incidence of cancer, particularly breast, prostate, and colorectal cancers.
