How Does Tumor Hypoxia Influence Treatment Strategies?
Given its role in therapy resistance, tumor hypoxia is a critical consideration in treatment planning. Strategies to overcome hypoxia include the use of hypoxia-activated prodrugs, which become active only in low oxygen conditions, and agents that normalize tumor vasculature to improve oxygen delivery. Additionally, researchers are exploring the potential of combining immunotherapy with hypoxia-targeted treatments to enhance immune cell infiltration and activation within hypoxic tumor regions.
