Are There Therapeutic Agents Targeting Tumor Hypoxia?
Indeed, several therapeutic agents are under investigation or in use to target tumor hypoxia. Tirapazamine is a notable example, a prodrug that becomes cytotoxic specifically under hypoxic conditions. Other therapies aim to disrupt hypoxia-induced pathways, such as inhibitors of HIF-1α or agents that impede angiogenesis. These treatments are designed to exploit the unique vulnerabilities of hypoxic tumor cells.
