Other sequencing methods, such as targeted gene panels and whole exome sequencing (WES), focus on specific regions of the genome. While these methods are less comprehensive than WGS, they are often more cost-effective and easier to interpret. WES, for example, sequences only the protein-coding regions of the genome, which represent about 1-2% of the total DNA but include most known disease-associated mutations. Targeted panels focus on a predefined set of genes known to be relevant to specific cancers.