BUB1B's role in the mitotic checkpoint makes it a key player in maintaining genomic stability. Dysregulation or mutations in the BUB1B gene can lead to chromosomal instability, which is a hallmark of many types of cancer. Overexpression or underexpression of BUB1B has been observed in various cancers, including breast cancer, colorectal cancer, and prostate cancer, suggesting its critical role in tumorigenesis.
