Management of CINV involves a combination of pharmacological and non-pharmacological approaches.
Pharmacological Interventions Antiemetic drugs are the cornerstone of CINV management. These include: - 5-HT3 Receptor Antagonists: Such as ondansetron and granisetron. - NK1 Receptor Antagonists: Such as aprepitant and fosaprepitant. - Corticosteroids: Such as dexamethasone. - Dopamine Antagonists: Such as metoclopramide. - Benzodiazepines: Such as lorazepam, particularly for anticipatory CINV.
Non-Pharmacological Interventions These approaches can complement drug therapy and include: - Dietary Modifications: Small, frequent meals and avoiding spicy foods. - Behavioral Therapy: Techniques like cognitive-behavioral therapy (CBT) and relaxation training. - Acupuncture and Acupressure: Some patients find relief through these methods.
