Diagnosis of colorectal carcinoma in situ typically involves several steps. Screening methods such as colonoscopy and sigmoidoscopy are crucial for early detection. During these procedures, doctors can visualize the inner lining of the colon and rectum and take biopsies of suspicious areas. Other diagnostic tools include stool tests that detect blood or DNA markers associated with cancer, and imaging tests like CT colonography. Pathological examination of biopsy samples is essential to confirm the diagnosis.