In the absence of a control group, efficacy in single arm studies is often measured using historical controls or benchmarks from previous studies. Key metrics include:
Response Rate: The proportion of patients whose cancer shrinks or disappears after treatment. Progression-Free Survival (PFS): The length of time during and after treatment that a patient lives with the disease without it getting worse. Overall Survival (OS): The length of time from the start of treatment that patients are still alive.
