In many types of cancer, EGFR is found to be overexpressed, mutated, or dysregulated. These abnormalities can lead to uncontrolled cell division and tumor growth. EGFR mutations are particularly common in non-small cell lung cancer (NSCLC), glioblastoma, and colorectal cancer. Overexpression of EGFR has also been observed in cancers of the head and neck, esophagus, and pancreas.
