How is GermlineCNVCaller Different from Somatic CNV Callers?
While somatic CNV callers focus on identifying copy number changes that occur in tumor cells, GermlineCNVCaller targets inherited CNVs that are present in all cells of an individual's body. Somatic CNVs are typically acquired during a person's lifetime and are specific to cancerous tissues. In contrast, germline CNVs are inherited from one's parents and are present in the germline DNA, making them relevant for understanding inherited cancer risks.