Liver cancer, particularly hepatocellular carcinoma (HCC), is a significant contributor to ESLD. HCC often arises in the context of underlying chronic liver disease, such as cirrhosis, which itself can be a result of long-term damage from hepatitis B or C, alcohol use, or non-alcoholic fatty liver disease (NAFLD). The presence of cancer exacerbates liver dysfunction, accelerating the progression to ESLD.