What is the Clinical Significance of Biallelic Mutations?
The presence of biallelic mutations has significant clinical implications. For instance, it can influence the choice of therapeutic strategies. Patients with biallelic inactivation of certain genes may respond differently to specific treatments. For example, tumors with biallelic inactivation of BRCA1 or BRCA2 genes are often sensitive to PARP inhibitors. Understanding the biallelic status of these genes can guide personalized treatment plans.
