Can You Give Examples of Biallelic Mutations in Cancer?
One of the classic examples of a biallelic mutation in cancer is the RB1 gene in retinoblastoma. In retinoblastoma, both alleles of the RB1 gene must be inactivated for the cancer to develop. Another example is the TP53 gene, commonly known as the "guardian of the genome," which requires mutations in both alleles to lose its function and contribute to various types of cancer.
