The procedure for LBC starts with the collection of cells from the targeted area, such as the cervix or other body sites. A special brush or spatula is used to scrape cells, which are then immersed in a vial containing a liquid preservative. The sample is transported to a laboratory, where it undergoes processing. The liquid medium is filtered or centrifuged to concentrate the cells, which are then evenly distributed on a slide for staining and examination under a microscope.