Multiple sampling can be performed through various methods such as biopsies, fine-needle aspirations, and surgical resections. Advanced imaging techniques like PET and MRI are often used to guide the sampling process, ensuring that different regions of the tumor are adequately sampled. Liquid biopsies, involving the analysis of circulating tumor DNA (ctDNA) or circulating tumor cells (CTCs), are also gaining popularity as a less invasive method of multiple sampling.
