The regulation of NADPH oxidase in cancer cells is complex and involves multiple mechanisms. These include transcriptional regulation, post-translational modifications, and interactions with other proteins. Oncogenic signaling pathways, such as RAS/RAF/MEK/ERK and PI3K/AKT, can upregulate NADPH oxidase activity, enhancing ROS production and promoting cancer cell survival and proliferation. Targeting these regulatory mechanisms may offer new avenues for cancer treatment.
