What are the Challenges in Targeting NADPH Oxidase in Cancer?
While targeting NADPH oxidase holds promise for cancer treatment, several challenges remain. One major challenge is the ubiquitous nature of NADPH oxidase, as it is involved in normal cellular functions, including immune response and host defense. Inhibiting its activity could have unintended effects on normal cells and tissues. Additionally, the development of specific and effective inhibitors that can selectively target cancer cells without affecting normal cells is critical for the success of NADPH oxidase-targeted therapies.
