How is NBD Used in Tumor Mutational Burden (TMB) Analysis?
Tumor mutational burden (TMB) is a measure of the number of mutations present in a tumor's genome. High TMB is often associated with better responses to immunotherapy. Researchers use the negative binomial distribution to model the count of mutations in tumor samples, accounting for overdispersion. This helps in identifying patients who are more likely to benefit from specific therapies and in understanding the underlying mechanisms of mutation accumulation.
