PDGFR signaling is implicated in various types of cancers. Abnormal activation of PDGFR, through either mutation or overexpression, can contribute to cancer development and progression. This abnormal activation can lead to uncontrolled cell proliferation, migration, and survival, hallmarks of cancer. PDGFR has been particularly studied in cancers such as glioblastoma, sarcomas, and leukemias.
